Simulating user interactions during dynamic analysis of a sample is disclosed. A sample is received for analysis. Prior to execution of the sample, a baseline screenshot of a system folder is generated by accessing frame buffer data stored on a graphics card. The sample is caused to execute, at least in part using one or more hypervisor instructions to move a pointing device to an icon associated with the sample. A current screenshot of the system folder is generated by accessing current frame buffer data stored on the graphics card.