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US Patent 11707480 Highly active compounds against COVID-19

Patent 11707480 was granted and assigned to Atea Pharmaceuticals, Inc. on July, 2023 by the United States Patent and Trademark Office.

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Patent Citations Received
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US Patent 12006340 Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
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 US Patent 11707480 Highly active compounds against COVID-19

Article

The present invention is the use of a small group of purine nucleotide phosphoramidate disclosed herein or a pharmaceutically acceptable salt thereof in an effective amount for the treatment or prevention of the novel 2019 coronavirus disease (COVID-19) in a host, for example a human, in need thereof.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Atea Pharmaceuticals, Inc.
Atea Pharmaceuticals, Inc.
0
Current Assignee
Atea Pharmaceuticals, Inc.
Atea Pharmaceuticals, Inc.
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
117074800
Date of Patent
July 25, 2023
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Patent Application Number
170945410
Date Filed
November 10, 2020
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Patent Citations
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US Patent 7094770 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
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US Patent 7105493 Methods and compositions for treating flaviviruses and pestiviruses
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US Patent 7105499 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 7125855 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 7138376 Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
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US Patent 7148206 Methods and compositions for treating flaviviruses and pestiviruses
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US Patent 7157441 Methods and compositions for treating hepatitis C virus
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US Patent 7163929 Methods and compositions for treating flaviviruses and pestiviruses
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US Patent 7169766 Methods and compositions for treating hepatitis C virus
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US Patent 7192936 Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
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US Patent 7202224 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 7211570 Treatment of EBV and KHSV infection
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US Patent 7268119 Tricyclic nucleosides or nucleotides as therapeutic agents
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US Patent 7285658 Nucleotide mimics and their prodrugs
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US Patent 7307065 2′-Fluoronucleosides
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US Patent 7323449 Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 7339054 Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates
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US Patent 7365057 Modified 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7384924 Modified 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7388002 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
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US Patent 7429571 Therapeutic furopyrimidines and thienopyrimidines
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US Patent 7429572 Modified fluorinated nucleoside analogues
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US Patent 7456155 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
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US Patent 7495006 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
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US Patent 7514410 Hepatitis C therapies
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US Patent 7534767 C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 7547704 Modified 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7560434 AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
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US Patent 7560550 Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives
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US Patent 7582618 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
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US Patent 7601820 Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives
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US Patent 7608597 Methods and compositions for treating hepatitis C virus
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US Patent 7608599 Antiviral phosphoramidates
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US Patent 7608600 Modified 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7608601 4′-Substituted nucleoside derivatives as inhibitors of HCV RNA replication
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US Patent 7625875 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7632821 Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection
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US Patent 7635689 Modified 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7638502 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
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US Patent 7652001 Pharmacologically active agents containing esterified phosphonates and methods for use thereof
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US Patent 7662798 2′ and 3′-nucleoside prodrugs for treating
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US Patent 7662938 2′-fluoronucleosides
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US Patent 7691603 Intracellular formation of peptide conjugates
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US Patent 7713941 Tricyclic nucleosides or nucleotides as therapeutic agents
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US Patent 7718790 Kit for assessing mitochondrial toxicity
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US Patent 7749983 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
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US Patent 7772208 2′,3′-dideoxynucleoside analogues for the treatment or prevention of
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US Patent 7824851 2′-branched nucleosides and Flaviviridae mutation
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US Patent 7842672 Phosphonate inhibitors of HCV
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US Patent RE42015 N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections
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US Patent 7879815 Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
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US Patent 7902202 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 7919247 Simultaneous quantification of nucleic acids in diseased cells
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US Patent 7932240 Phosphadiazine HCV polymerase inhibitors IV
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US Patent 7951789 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 7964580 Nucleoside phosphoramidate prodrugs
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US Patent 7973013 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
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US Patent 7994139 Antiviral therapeutic agents
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US Patent 8008264 1′-substituted carba-nucleoside analogs for antiviral treatment
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US Patent 8012941 Carba-nucleoside analogs for antiviral treatment
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US Patent 8012942 Carba-nucleoside analogs for antiviral treatment
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US Patent 8071567 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication
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US Patent 8071568 Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
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US Patent 8093380 Compounds with the bicyclo[4.2.1]nonane system for the treatment of
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US Patent 8114994 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation
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US Patent 8114997 N
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US Patent 8119607 Bicyclic nucleosides and nucleotides as therapeutic agents
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US Patent 8133870 Therapeutic furopyrimidines and thienopyrimidines
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US Patent 8148349 Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
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US Patent 8163703 Hepatitis C therapies
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US Patent 8168583 2-fluoronucleosides
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US Patent 8173621 Nucleoside cyclicphosphates
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US Patent 8193372 Phosphothiophene and phosphothiazole HCV polymerase inhibitors
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US Patent 8242085 Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer
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US Patent 8299038 Methods and compositions for treating hepatitis C virus
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US Patent 8318682 1′substituted carba-nucleoside analogs for antiviral treatment
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US Patent 8324179 Nucleoside analogs for antiviral treatment
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US Patent 8334270 Nucleoside phosphoramidate prodrugs
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US Patent 8343937 Methods and compositions for treating flaviviruses and pestiviruses
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US Patent 8362068 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
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US Patent 8399428 Nucleosides with antiviral and anticancer activity
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US Patent 8399429 Uracyl cyclopropyl nucleotides
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US Patent 8415308 1′-substituted-carba-nucleoside prodrugs for antiviral treatment
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US Patent 8415309 Bicyclic nucleosides and nucleotides as therapeutic agents
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US Patent 8415321 Nucleoside derivatives for treatment of
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US Patent 8415322 Modified fluorinated nucleoside analogues
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US Patent 8431588 Cyclopropyl polymerase inhibitors
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US Patent 8440813 Antiviral nucleoside analogs
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US Patent 8455451 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
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US Patent 8470834 AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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US Patent 8481510 Uracyl spirooxetane nucleosides
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US Patent 8481712 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
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US Patent 8481713 Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives
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US Patent 8492539 Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
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US Patent 8501699 Bicyclic nucleosides and nucleotides as therapeutic agents
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US Patent 8507460 Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 8541434 Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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US Patent 8551973 Nucleoside analogs
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US Patent 8552021 Phosphoramidate derivatives of nucleosides
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US Patent 8563530 Purine nucleoside phosphoramidate
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US Patent 8575119 2′-chloroacetylenyl substituted nucleoside derivatives
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US Patent 8580765 Nucleoside phosphoramidate prodrugs
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US Patent 8609627 Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
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US Patent 8618076 Nucleoside phosphoramidates
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US Patent 8629263 Nucleoside phosphoramidates
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US Patent 8633309 Nucleoside phosphoramidates
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US Patent 8637475 Modified 2′ and 3′ nucleoside prodrugs for treating flaviviridae infections
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US Patent 8642756 Nucleoside phosphoramidates
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US Patent 8658616 Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus
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US Patent 8673926 Spiro[2.4]heptanes for treatment of flaviviridae infections
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US Patent 8674085 2′-branched nucleosides and
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US Patent 8680071 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 8691788 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 8697694 Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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US Patent 8715638 Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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US Patent 8716262 Nucleoside phosphoramidates
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US Patent 8716263 Synthesis of purine nucleosides
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US Patent 8735345 Therapeutic composition
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US Patent 8735372 Nucleoside phosphoramidate prodrugs
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US Patent 8735569 Nucleoside phosphoramidates
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US Patent 8742101 Purine nucleoside analogues for treating
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US Patent 8759318 Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
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US Patent 8759372 None
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US Patent 8759510 Nucleoside cyclicphosphates
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US Patent 8765710 2′,4′-substituted nucleosides as antiviral agents
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US Patent 8772474 Cyclic nucleotide analogs
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US Patent 8802840 Bicyclic nucleosides and nucleotides as therapeutic agents
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US Patent 8815829 3′-azido purine nucleotide prodrugs for treatment of viral infections
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US Patent 8816074 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
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US Patent 8841275 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
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US Patent 8846638 Macrocyclic nucleoside phosphoramidate derivatives
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US Patent 8846896 Methods of preparing substituted nucleotide analogs
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US Patent 8853171 1′-substituted carba-nucleoside analogs for antiviral treatment
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US Patent 8859595 Potent and selective inhibitors of hepatitis C virus
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US Patent 8859756 Stereoselective synthesis of phosphorus containing actives
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US Patent 8871737 Substituted nucleotide analogs
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US Patent 8871785 Antiviral phosphonate analogs
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US Patent 8877731 Azido nucleosides and nucleotide analogs
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US Patent 8877733 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
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US Patent 8889159 Compositions and methods for treating hepatitis C virus
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US Patent 8889701 Substituted (S)-(2R,3R,5R)-3-hydroxy-(5-pyrimidin-1-yl)tetrahydrofuran-2-ylmethyl aryl phosphoramidate
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US Patent 8895531 2′-fluoronucleoside phosphonates as antiviral agents
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US Patent 8895723 Methods of preparing substituted nucleotide analogs
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US Patent 8906880 Nucleoside phosphoramidate prodrugs
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US Patent 8912321 Preparation of nucleosides ribofuranosyl pyrimidines
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US Patent 8921384 Spiro[2.4]heptanes for treatment of flaviviridae infections
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US Patent 8927513 5′ phosphate mimics
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US Patent 8933052 Uracyl spirooxetane nucleosides
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US Patent 8946244 2′-fluoro-6′methylene carbocyclic nucleosides and methods of treating viral infections
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US Patent 8951985 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 8957045 Nucleoside phosphoramidates
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US Patent 8957046 Nucleoside phosphoramidate prodrugs
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US Patent 8980865 Substituted nucleotide analogs
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US Patent 9012427 Pharmaceutical combinations comprising a thionucleotide analog
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US Patent 9012428 Uracyl spirooxetane nucleoside phosphoramidates
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US Patent 9045520 Synthesis of purine nucleosides
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US Patent 9061041 2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
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US Patent 9085573 Nucleoside phosphoramidate prodrugs
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US Patent 9085599 2′allene-substituted nucleoside derivatives
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US Patent 9090642 Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
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US Patent 9109001 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
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US Patent 9139604 Antiviral phosphonate analogs
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US Patent 9156872 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
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US Patent 9173893 Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
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US Patent 9187515 2′,4′-fluoro nucleosides for the treatment of HCV
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US Patent 9192621 Esters and malonates of SATE prodrugs
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US Patent 9211300 4′-fluoro nucleosides for the treatment of HCV
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US Patent 9243025 Compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 9249174 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9339541 Thiophosphate nucleosides for the treatment of HCV
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US Patent 9351989 Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
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US Patent 9403863 Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
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US Patent 9408863 5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
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US Patent 9447132 Highly active nucleoside derivative for the treatment of HCV
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US Patent 9598457 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9603863 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9603864 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9758544 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9815864 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 9822137 Phosphonucleosides useful in the treatment of viral disorders
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US Patent 9828410 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N
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US Patent 9890188 Substituted nucleosides, nucleotides and analogs thereof
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US Patent 10000523 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N
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US Patent 10005810 Process for preparing nucleoside prodrugs
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US Patent 10005811 β-D-2′-deoxy-2′-α-fluoro-2′β-C-substituted-2-modified-N
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US Patent 10202412 β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N
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US Patent 10239911 Beta-D-2′-deoxy-2′-alpha-fluoro-2′-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
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US Patent 10519186 Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus
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US Patent 10815266 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N
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US Patent 10870672 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
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US Patent 10870673 β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N
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US Patent 10874687 Highly active compounds against COVID-19
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US Patent 10875885 β-d-2′-deoxy-2′-α-fluoro-2′-β-c-substituted-2-modified-n
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US Patent 10894804 Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus
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US Patent 10906928 Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus
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US Patent 10946033 2′-substituted-N6-substituted purine nucleotides for RNA virus treatment
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Patent Primary Examiner
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Patrick T. Lewis
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