US Patent 11712692 Sample collection system including sealing cap and valve

A biological sample collection system can include a sample collection vessel having an opening configured to receive a biological sample and a selectively movable valve configured to at least partially associate with the opening of the sample collection vessel. The selectively movable valve can include a post and a valve head associated with a distal portion of the post. The system can additionally include a sealing cap configured to associate with the selectively movable valve and with the sample collection vessel. The sealing cap can include a reagent chamber for storing a measure of sample preservation reagent and associating the sealing cap with the sample collection vessel causes a physical rearrangement of the post and the valve head such that a fluid vent associated with the post aligns with an aperture defined by the valve head allowing fluid communication between the reagent chamber and the sample collection vessel.