A vehicle location and control system determines a signal-derived separation distance between antennas disposed onboard a vehicle based on signals received by the antennas from an off-board source. The system determines an input-derived separation distance between the antennas based on input offset distances of the antennas from a designated location on the vehicle, determines a difference between the input-derived separation distance and the signal-derived separation distance, and activates or deactivates an automated route identification system that determines which route of several different routes that the vehicle is disposed upon based on the difference that is determined.