Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hunter Fraser
Zachery Smith
Date of Patent
September 19, 2023
Patent Application Number
16293550
Date Filed
March 5, 2019
Patent Citations
Patent Primary Examiner
Patent abstract
The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.
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