A modular configurable hospital system is provided. The system comprises at least one unit. The system is configured with at least one patient care unit, which comprises at least one of a patient care room and a ward. The patient care units are sealably configured into at least one patient care section, and arranged end to end. A support care section, having at least one support care unit, may be provided for providing space for working, storage and other services for those working in the system. The system may be sealably configured in numerous combinations to adapt to the immediate needs of the situation, and installed indoors and in the external environment. A method of operation of the system is provided.