A protective guard for a medical tubing connector includes a ring, at least one flexible member attached at a first end to the ring and having a second end, and a base attached to the second end of the at least one flexible member. The ring is configured to fit over a first connection member of the medical tubing connector, while the base is configured to fit over a second connection member of the medical tubing connector. When coupled with the medical tubing connector, the protective guard helps prevent a user from touching the medical tubing connector.