Self-aligning plating systems and methods are disclosed. The self-aligning plating system may include an interbody spacer, a medical device plate, and an insertion member. The interbody spacer may be inserted between a top vertebra and a bottom vertebra of a patient's spinal column. A medical device plate may slide along an insertion member in operable connectivity with the interbody spacer so that the medical device plate comes into contact with and can be secured to the patient's anatomy.