Motor vehicles may be equipped with running board activated powered closure member systems. A powered opening or closing sequence of a closure member may be initiated by activating a running board assembly of the powered closure member system in response to a user input. The user input can be provided by a limb of the user, for example. In some embodiments, the running board assembly may include integrated sensors for receiving the user input. In other embodiments, the running board assembly may be configured to function as a switch for receiving the user input.