Hygienic standoffs to seal nuts, bolts, anchor brackets, and other mounting hardware used within tube and pipe hanger systems within industrial manufacturing facilities that require clean, sanitary, and sterile environments and more specifically to hygienic standoffs that do not require the use of caulk, adhesives, acrylic latex, silicone, polyurethane, rubber, or other sealing compounds. The hygienic standoffs instead seal to a pipe, tube, or other surface using an interlocking ridged seal of elastomeric material to form a watertight seal preventing the buildup of dirt, liquid, bacteria, and other contaminants.