A sanitizing shield for a vehicle includes a separation surface configured to at least partially shroud a shielded seat. The separation surface has an inner seat facing side and an outer shielding side. The sanitizing shield includes a sanitization station coupled to the separation surface. The sanitizing shield can have one or more of a hand sanitizer dispenser, an air purifier, and/or an ultraviolet-C (UVC) sanitizer. The sanitizing shield provides for improved physical separation within the passenger cabin while enhancing the sanitization potential available to rear passengers of the vehicle.