Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sachdev S. Sidhu
Andrew Emili
Kyrylo Zagorovsky
Megan McLaughlin
Warren C. W. Chan
Jonathan Buchanan Olsen
Date of Patent
October 31, 2023
Patent Application Number
16686549
Date Filed
November 18, 2019
Patent Citations
...
Patent Primary Examiner
Patent abstract
The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes. Each probe selectively binds to an N-terminal amino acid or an N-terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the N-terminal amino acid or N-terminal amino acid derivative of the polypeptide. Also provided are methods for the sequencing a plurality of polypeptide molecules in a sample and probes specific for N-terminal amino acids or N-terminal amino acid derivatives.
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