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US Patent 11834473 Engineered O-glycosylation in recombinant polypeptides and uses thereof

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Thomas Vincent Murray0

Daniel Higazi0

Monika Papworth0

Emmanuel Rossy0

Adam Tibbles0

Katarzyna Anna Kozakowska0

Date of Patent

December 5, 2023

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Patent Application Number

169560060

Date Filed

December 20, 2018

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Patent Citations

US Patent 9187532 Glycosylation of peptides via O-linked glycosylation sequences

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Patent Primary Examiner

Tekchand Saidha

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CPC Code

0

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Patent abstract

The present invention relates to recombinant polypeptide therapeutics having an engineered O-linked amino acid (AA) glycosylation sequence (motif), which is covalently linked to O-glycan(s) (tag). Recombinant O-glycosylated polypeptides may be produced in mammalian cells to present natural or un-natural O-glycan structures through metabolic labelling.

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