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US Patent 11851690 Systems and methods for the treatment of hemoglobinopathies

Patent 11851690 was granted and assigned to Editas Medicine on December, 2023 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

Editas Medicine

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Current Assignee

Editas Medicine

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Jack Heath0

Edouard Aupepin De Lamothe-Dreuzy0

Jennifer Leah Gori0

Luis A. Barrera0

Date of Patent

December 26, 2023

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Patent Application Number

165693360

Date Filed

September 12, 2019

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Patent Citations

US Patent 8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes

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US Patent 8889394 Multiple domain proteins

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US Patent 8889418 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation

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US Patent 8895308 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation

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US Patent 8906616 Engineering of systems, methods and optimized guide compositions for sequence manipulation

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US Patent 8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes

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US Patent 8945839 CRISPR-Cas systems and methods for altering expression of gene products

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US Patent 8993233 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains

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Patent Primary Examiner

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CPC Code

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Patent abstract

Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.

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