Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Dehua Pei0
Date of Patent
January 2, 2024
0Patent Application Number
171365780
Date Filed
December 29, 2020
0Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
Anticachexin C1 inhibits the TNFα-TNFα receptor interaction. In this work, analogs of anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNFα TNFα-induced cell death, NF-κB activation, and c-Jun N-terminal kinase (JNK) signaling in cultured mammalian cells. Methods of using the bicyclic peptide anticachexin C1 analogs to treat cancer, inflammatory disorders and immune disorders are also described.
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