Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
James Clarke0
Brian McKeown0
Stephen Cheley0
James White0
John Hagan Pryce Bayley0
Lakmal Jayasinghe0
Date of Patent
January 2, 2024
0Patent Application Number
173556680
Date Filed
June 23, 2021
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing.
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