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US Patent 11866754 Trinucleotide mRNA cap analogs

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 US Patent 11866754 Trinucleotide mRNA cap analogs

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Patent abstract

The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118667540
Patent Inventor Names
Edward John Miracco0
Gabor Butora0
Matthew Stanton0
Date of Patent
January 9, 2024
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Patent Application Number
157682060
Date Filed
October 17, 2016
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Patent Citations
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US Patent 8202979 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
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US Patent 8217016 Application of mRNA for use as a therapeutic agent for tumorous diseases
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US Patent 8273866 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
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US Patent 8278036 RNA containing modified nucleosides and methods of use thereof
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US Patent 8304529 Dinucleotide MRNA cap analogs
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US Patent 8404651 Compositions and methods for treating viral infections
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US Patent 8691966 RNA containing modified nucleosides and methods of use thereof
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US Patent 8748089 RNA containing modified nucleosides and methods of use thereof
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US Patent 8835108 RNA containing modified nucleosides and methods of use thereof
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US Patent 8853179 Reengineering mRNA primary structure for enhanced protein production
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US Patent 8859229 Transient transfection with RNA
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US Patent 8883506 Kits comprising linear DNAs for sustained polypeptide expression using synthetic, modified RNAs
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US Patent 8969545 Alkynyl-derivatized cap analogs, preparation and uses thereof
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US Patent 9138442 Compositions and methods for treating viral infections
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US Patent 9192661 Delivery of self-replicating RNA using biodegradable polymer particles
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US Patent 9295717 Vaccine composition comprising 5′-cap modified RNA
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US Patent 9388420 Alkynyl-derivatized cap analogs, preparation and uses thereof
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US Patent 9476055 Modification of RNA, producing an increased transcript stability and translation efficiency
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US Patent 9539276 Compositions and methods for treating viral infections
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US Patent 9597380 Terminally modified RNA
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US Patent 9751925 Alternative nucleic acid molecules containing reduced uracil content and uses thereof
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US Patent 10106800 Modification of RNA, producing an increased transcript stability and translation efficiency
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US Patent 10143758 Liver specific delivery of messenger RNA
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US Patent 10155029 Terminally modified RNA
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US Patent 10188748 Pharmaceutical composition containing a stabilised mRNA optimised for translation in its coding regions
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US Patent 10286086 Alternative nucleic acid molecules and uses thereof
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US Patent 10428106 Phosphate replacement mRNA cap analogs
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US Patent 10519189 Compositions and methods for synthesizing 5′-Capped RNAs
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US Patent 7074596 Synthesis and use of anti-reverse mRNA cap analogues
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Patent Primary Examiner
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Pancham Bakshi
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CPC Code
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C12N 15/113
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C12N 15/1096
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C12P 19/34
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