Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Mitesh Borad0
Jessica Aldrich0
Alan Bryce0
David Craig0
Sara Byron0
John Carpten0
Keith Stewart0
George Vasmatzis0
...
Date of Patent
January 9, 2024
0Patent Application Number
174114470
Date Filed
August 25, 2021
0Patent Citations
Patent Primary Examiner
Patent abstract
Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.
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