Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Joseph C. Glorioso, III0
Justus B. Cohen0
Hiroaki Uchida0
Paola Grandi0
Date of Patent
January 30, 2024
0Patent Application Number
169854590
Date Filed
August 5, 2020
0Patent Citations
Patent Primary Examiner
Patent abstract
The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
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