An information handling system utilizes data with a cache line size. A memory module is coupled to a memory controller by a memory bus, and stores and retrieves data with a memory line size. The cache line size is an integer multiple of the memory line size. The memory controller calculates error correction code data for each memory line of user data, and generates metadata related to the user data for chunks of data that are equal to an integer number (N) of cache lines, where N is greater than one.