The disclosed technology provides solutions for protecting the health of ride-sharing passengers by detecting passenger illnesses, and taking precautions to safely address potentially exposed vehicles. A process of the disclosed technology can include steps for: collecting sensor-data corresponding with one or more AV passengers, determining a likelihood that at least one of the AV passengers is suffering from a physical illness, and transmitting a wellness notification to a fleet management system if the likelihood exceeds a predetermined threshold. Systems and machine-readable media are also provided.