Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeannie T. Lee0
Lieselot Carrette0
Anand Minajigi0
Date of Patent
February 27, 2024
0Patent Application Number
172143200
Date Filed
March 26, 2021
0Patent Citations
...
Patent Primary Examiner
Patent abstract
Methods for reactivating genes on the inactive X chromosome that include administering one or both of a DNA methyltransferase (DNMT) Inhibitor and/or a topoisomerase inhibitor, e.g., etoposide and/or 5′-azacytidine (aza), optionally in combination with an inhibitor of XIST RNA and/or an Xist-interacting protein, e.g., a chromatin-modifying protein, e.g., a small molecule or an inhibitory nucleic acid (such as a small inhibitory RNA (siRNAs) or antisense oligonucleotide (ASO)) that targets XIST RNA and/or a gene encoding an Xist-interacting protein, e.g., a chromatin-modifying protein.
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