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US Patent 11913045 Engineered phenylalanine ammonia lyase polypeptides

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 US Patent 11913045 Engineered phenylalanine ammonia lyase polypeptides

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Patent abstract

The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119130450
Patent Inventor Names
Benjamin Mijts0
Gjalt W. Huisman0
Jonathan Vroom0
Nicholas J. Agard0
Xiyun Zhang0
Date of Patent
February 27, 2024
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Patent Application Number
170099250
Date Filed
September 2, 2020
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Patent Citations
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US Patent 7105297 Methods and compositions for cellular and metabolic engineering
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US Patent 7148054 Evolution of whole cells and organisms by recursive sequence recombination
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US Patent 7288375 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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US Patent 7421347 Identifying oligonucleotides for in vitro recombination
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US Patent 7430477 Methods of populating data structures for use in evolutionary simulations
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US Patent 7531341 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
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US Patent 7534564 Methods and compositions for polypeptide engineering
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US Patent 7534595 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
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US Patent 7537923 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
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US Patent 7553653 Variants and chemically-modified variants of phenylalanine ammonia-lyase
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US Patent 7560263 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
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US Patent 7620500 Optimization of crossover points for directed evolution
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US Patent 7620502 Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure
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US Patent 7629170 Evolution of whole cells and organisms by recursive sequence recombination
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US Patent 7702464 Method and apparatus for codon determining
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US Patent 7747391 Methods, systems, and software for identifying functional biomolecules
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US Patent 7747393 Methods, systems, and software for identifying functional biomolecules
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US Patent 7751986 Methods, systems, and software for identifying functional biomolecules
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US Patent 7776598 Methods and compositions for polypeptide engineering
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US Patent 7783428 Methods, systems, and software for identifying functional biomolecules
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US Patent 7790433 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
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US Patent 7795030 Methods and compositions for cellular and metabolic engineering
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US Patent 7853410 Method for making polynucleotides having desired characteristics
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US Patent 7868138 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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US Patent 7873499 Methods of populating data structures for use in evolutionary simulations
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US Patent 7904249 Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedures
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US Patent 7957912 Methods for identifying and producing polypeptides
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US Patent 8383346 Combined automated parallel synthesis of polynucleotide variants
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US Patent 9611468 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10144924 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10160963 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10294468 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10358639 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10487319 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10494623 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10640759 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 10717974 Engineered phenylalanine ammonia lyase polypeptides
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US Patent 6946296 Methods and compositions for polypeptide engineering
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US Patent 6995017 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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US Patent 7024312 Methods for making character strings, polynucleotides and polypeptides having desired characteristics
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US Patent 7058515 Methods for making character strings, polynucleotides and polypeptides having desired characteristics
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Patent Primary Examiner
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Kagnew H Gebreyesus
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