A self-powered sensing and transmitting device is provided and includes a piezoelectric generator, a carrying structure stacked with the piezoelectric generator, an encapsulation support structure including an encapsulation portion encapsulating the piezoelectric generator and the carrying structure and two supporting portions connected to two ends of the encapsulation portion, and a fixed support structure for being correspondingly coupled with the two supporting portions and fixed on a flexible surface. The self-powered sensing and transmitting device can be applied to a tire monitoring system and a motion monitoring system.