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US Patent 11919839 Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

Patent 11919839 was granted and assigned to Valo Health on March, 2024 by the United States Patent and Trademark Office.

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 US Patent 11919839 Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

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Patent abstract

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Valo Health
Valo Health
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Current Assignee
Valo Health
Valo Health
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119198390
Patent Inventor Names
Aleksandra Rudnitskaya0
Bingsong Han0
Cuixian Liu0
David R. Lancia, Jr.0
Jennifer R. Thomason0
Kenneth W. Bair0
Mary-Margaret Zablocki0
Matthew W. Martin0
Nicholas Barczak0
Pui Yee Ng0
Xiaozhang Zheng0
Date of Patent
March 5, 2024
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Patent Application Number
172385290
Date Filed
April 23, 2021
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Patent Citations
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US Patent 7135493 HDAC inhibitor
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US Patent 8497295 Spiroindoline modulators of muscarinic receptors
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US Patent 8513297 Biaromatic compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
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US Patent 8551988 Benzimidazole derivatives: preparation and pharmaceutical applications
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US Patent 8592399 S1P receptors modulators and their use thereof
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US Patent 8637547 Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases
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US Patent 8686025 Therapeutic lactams
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US Patent 8716323 Cyclic protein tyrosine kinase inhibitors
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US Patent 8754237 Bifunctional histone deacetylase inhibitors
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US Patent 8765810 Tumor necrosis factor inhibitors
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US Patent 8835501 Pharmaceutical formulations of HDAC inhibitors
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US Patent 8853415 Modulators of ATP-binding cassette transporters
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US Patent 8912331 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of protein kinases
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US Patent 8927576 HCV inhibitor and therapeutic agent combinations
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US Patent 9630922 3-spiro-7-hydroxamic acid tetralins as HDAC inhibitors
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Patent Primary Examiner
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Brian J Davis
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CPC Code
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C07C 259/06
0

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