Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jinsheng Weng0
Kelsey Moriarty0
Sattva S. Neelapu0
Date of Patent
March 5, 2024
0Patent Application Number
169610880
Date Filed
January 9, 2019
0Patent Citations
...
Patent Primary Examiner
Patent abstract
Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind the T-cell leukemia/lymphoma 1 (TCL1) oncoprotein. The TCR may be utilized in various therapies, such as autologous TCL1-TCR adoptive T cell therapy, to treat a cancer, such as a B-cell malignancy or a solid tumor expressing TCL1. Methods for expanding a population of T cells that target TCL1 are also provided.
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