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US Patent 11919948 Isoform-selective anti-TGFβ antibodies and methods of use

Patent 11919948 was granted and assigned to Genentech on March, 2024 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Wendy Green Halpern0

Wei-Ching Liang0

Patrick J. Lupardus0

Dhaya Seshasayee0

Yan Wu0

Daryle Depianto0

WeiYu Lin0

Tulika Tyagi0

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Date of Patent

March 5, 2024

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Patent Application Number

172056630

Date Filed

March 18, 2021

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Patent Citations

US Patent 10738110 PAC1 antibodies and uses thereof

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US Patent 10723793 TGF-β3 specific antibodies and methods and uses thereof

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US Patent 7527791 Humanized anti-TGF-beta antibodies

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US Patent 8012482 Humanized anti-TGF-beta antibodies

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US Patent 8198412 Antibodies that recognize cutting edge within the TGF-β activation controlling region

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US Patent 9090685 Antibodies to TGF-beta

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US Patent 9085625 Antibody variants having modifications in the constant region

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Patent Primary Examiner

Marianne P Allen

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Patent abstract

The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.

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