US Patent 11923048 Determining mucopolysaccharidoses and decision support tool

A diagnostic and decision support technology is provided for determining the presence, identity, and/or severity of an inherited lysosomal storage disorder. In particular, a mechanism is provided to detect and classify a lysosomal storage disorder in a human patient, which utilizes a logistic regression classifier determined based on a multi-variable-composite-biomarker comprising a specific set of physiological variables of the patient. This multi-variable statistical predictive biomarker approach may be employed for identifying persons whose attributes are consistent with features or lysosomal storage diseases, such as attenuated mucopolysaccharidosis Type 1 (Hurler-Scheie or Scheie syndromes).