Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
John Williams0
Ulrich Rodeck0
Kurt Jenkins0
Miso Park0
Date of Patent
March 12, 2024
0Patent Application Number
159310770
Date Filed
May 13, 2020
0Patent Citations
Patent Primary Examiner
Patent abstract
Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.
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