Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
David Bienvenue0
Danielle Mitchell0
John W. Blankenship0
Peter Pavlik0
Catherine J. McMahan0
Gabriela Hernandez-Hoyos0
Elaine T. Sewell0
Date of Patent
March 26, 2024
0Patent Application Number
175574400
Date Filed
December 21, 2021
0Patent Citations
Patent Primary Examiner
Patent abstract
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.