Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael C. Jensen0
Yvonne Y. Chen0
Eugenia Zah0
Date of Patent
April 2, 2024
0Patent Application Number
182382100
Date Filed
August 25, 2023
0Patent Citations
...
Patent Primary Examiner
Patent abstract
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
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