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US Patent 11964026 Layer-by-layer nanoparticles for cytokine therapy in cancer treatment

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Antonio Eric Barberio0

Santiago Correa Echavarria0

Darrell J. Irvine0

Mariane Bandeira Melo0

Paula T. Hammond0

Talar Tokatlian0

Erik Christopher Dreaden0

Date of Patent

April 23, 2024

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Patent Application Number

178924960

Date Filed

August 22, 2022

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Patent Citations

US Patent 7045087 Assembly of free-standing films using a layer-by-layer process

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US Patent 8105652 Methods of making decomposable thin films of polyelectrolytes and uses thereof

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US Patent 8685538 Stable polyelectrolyte coated nanoparticles

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US Patent 9198875 Controlled delivery of bioactive agents from decomposable films

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US Patent 9320750 Compositions and methods of treatment of drug resistant cancers

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US Patent 9393217 Self assembled films for protein and drug delivery applications

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US Patent 9463244 Compositions and methods for nucleic acid delivery

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US Patent 9610252 Multilayer compositions, coated devices and use thereof

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Patent Primary Examiner

Celeste A Roney

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Patent abstract

Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.

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