Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gordon Yiu Kon Ng0
Eric Escobar-Cabrera0
Mario Sanches0
Nina E. Weisser0
Surjit Bhimarao Dixit0
Grant Raymond Wickman0
Date of Patent
April 23, 2024
0Patent Application Number
171845080
Date Filed
February 24, 2021
0Patent Citations
...
Patent Primary Examiner
Patent abstract
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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