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US Patent 11970722 Engineered acid alpha-glucosidase variants

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Rachel Cathleen Botham0

Nikki Dellas0

David William Homan0

Chinping Chng0

William Casey Hallows0

Adam P. Silverman0

Jessica P. Lao0

Yu Zhu0

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Date of Patent

April 30, 2024

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Patent Application Number

171266470

Date Filed

December 18, 2020

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Patent Citations

US Patent 7430477 Methods of populating data structures for use in evolutionary simulations

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US Patent 8048674 Methods and compositions for cellular and metabolic engineering

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US Patent 8058001 Oligonucleotide mediated nucleic acid recombination

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US Patent 8076138 Evolution of whole cells and organisms by recursive sequence recombination

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US Patent 8108150 Optimization of crossover points for directed evolution

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US Patent 8170806 Methods of populating data structures for use in evolutionary simulations

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US Patent 8224580 Optimization of crossover points for directed evolution

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US Patent 8377681 Evolution of whole cells and organisms by recursive sequence recombination

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Patent Primary Examiner

Tekchand Saidha

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CPC Code

0

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Patent abstract

The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

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