An injection device and method are shown. Devices and methods include a forceps and a needle advancement mechanism to clamp a portion of tissue and control a depth of penetration of the needle between gripping ends of the forceps. An injection device and method are shown where selected components of the injection device such as a syringe and forceps are disposable, while the remaining portions of the injection device are reusable. Devices and methods are shown that utilize micro-needles to control a depth of penetration.