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US Patent 11977074 Affinity-based detection of ligand-encoded synthetic biomarkers

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Sangeeta N. Bhatia0

Gabriel A. Kwong0

David K. Wood0

Andrew David Warren0

Kevin Y. Lin0

Date of Patent

May 7, 2024

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Patent Application Number

166917880

Date Filed

November 22, 2019

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Patent Citations

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US Patent 11428689 Methods and uses for remotely triggered protease activity measurements

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US Patent 11448643 Methods to specifically profile protease activity at lymph nodes

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US Patent 11519905 Methods to spatially profile protease activity in tissue and sections

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US Patent 11549947 Multiplexed detection with isotope-coded reporters

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US Patent 11549951 Methods and products for in vivo enzyme profiling

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Patent Primary Examiner

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Patent abstract

The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.

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