Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Timothy Weeden0
Cody A. Desjardins0
John Najim0
Mohammed T. Qatanani0
Brendan Quinn0
Romesh R. Subramanian0
Date of Patent
May 21, 2024
0Patent Application Number
183496310
Date Filed
July 10, 2023
0Patent Citations
0
0
0
0
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Patent Citations Received
Patent Primary Examiner
Patent abstract
Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload promotes the expression or activity of a functional dystrophin protein. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide, e.g., an oligonucleotide that causes exon skipping in a mRNA expressed from a mutant DMD allele.
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