Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vincent Christopher Luca0
Kenan Christopher Garcia0
Date of Patent
May 28, 2024
0Patent Application Number
164765010
Date Filed
January 11, 2018
0Patent Citations
Patent Primary Examiner
Patent abstract
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.
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