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US Patent 11993653 Antibodies and methods of use thereof

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 US Patent 11993653 Antibodies and methods of use thereof

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Patent abstract

Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119936530
Patent Inventor Names
Cornelia Anne Mundt0
David Adam Savitsky0
David Schaer0
Gerd Ritter0
Igor Proscurshim0
Jean-Marie Cuillerot0
Jedd David Wolchok0
Marc Van Dijk0
Mark Arthur Findeis0
Nicholas Stuart Wilson0
Olga Shebanova0
Rikke Baek Holmgaard0
Roberta Zappasodi0
Taha Merghoub0
Date of Patent
May 28, 2024
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Patent Application Number
164351750
Date Filed
June 7, 2019
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Patent Citations
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US Patent 7332582 Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
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US Patent 7521051 Methods of upmodulating adaptive immune response using anti-PD-1 antibodies
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US Patent 7595048 Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
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US Patent 7851598 Receptor modulators
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US Patent 7858746 Substance that specifically recognizes PD-1
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US Patent 8008449 Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
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US Patent 8168757 PD-1 binding proteins
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US Patent 8354509 Antibodies to human programmed death receptor PD-1
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US Patent 8617546 Anticancer agent comprising anti-PD-1 antibody or anti-PD-L1 antibody
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US Patent 8735553 Anti-PD1 antibodies and their use as therapeutics and diagnostics
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US Patent 8741295 PD-1 antibodies and PD-L1 antibodies and uses thereof
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US Patent 8927697 PD-1 specific antibodies and uses thereof
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US Patent 8993731 PD-1 antibody
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US Patent 9067998 Targeting PD-1 variants for treatment of cancer
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US Patent 9084776 Methods for treating cancer using anti-PD-1 antibodies
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US Patent 9102727 Human anti-PD-1 antibodies and uses therefor
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US Patent 9132281 Focused radiation for augmenting immune-based therapies against neoplasms
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US Patent 9163087 Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
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US Patent 9181342 PD-1 specific antibodies and uses thereof
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US Patent 9220776 Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments
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US Patent 9243052 Method for treating and diagnosing hematologic malignancies
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US Patent 9358289 Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies
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US Patent 9381244 VISTA modulators for diagnosis and treatment of cancer
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US Patent 9394365 Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
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US Patent 9499603 PD-1 antibodies
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US Patent 9580504 Pidilizumab monoclonal antibody therapy following stem cell transplantation
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US Patent 9605070 Antibody molecules to TIM-3 and uses thereof
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US Patent 9676853 Antigen binding proteins that bind PD-1
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US Patent 9683048 Antibody molecules to PD-1 and uses thereof
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US Patent 9701749 Therapeutic agent for autoimmune diseases comprising PD-1 agonist
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US Patent 9771425 Anti-PD-1 antibodies
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US Patent 9815898 Antibody molecules to PD-1 and uses thereof
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US Patent 10323091 Anti-PD-1 antibodies and methods of use thereof
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US Patent 10703971 Chemiluminescent substrates
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US Patent 10912831 Anti-CTLA-4 antibodies and methods of use thereof
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US Patent 11013802 Anti-CTLA-4 antibodies and methods of use thereof
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US Patent 11345755 Anti-PD-1 antibodies and methods of use thereof
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US Patent 11638755 Anti-CTLA-4 antibodies and methods of use thereof
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US Patent 7029674 Methods for downmodulating immune cells using an antibody to PD-1
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Patent Primary Examiner
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Marianne P Allen
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