Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
J. Yun Tso0
Naoya Tsurushita0
Date of Patent
May 28, 2024
0Patent Application Number
176945700
Date Filed
March 14, 2022
0Patent Citations
Patent Primary Examiner
Patent abstract
The invention provides bifunctional molecules including an antibody specifically binding to CD122 and an extracellular domain of CTLA-4. The bifunctional molecules specifically bind to CD122 and CTLA-4 ligands, CD80 and CD86 and inhibit their function in immune activation. The bifunctional molecules can inhibit interaction of CD122 with its ligands IL-2 and IL-15 and inhibit interaction of CD80 and CD86 with their counter-receptor, CD28. These bifunctional molecules can suppress Signals 2 and 3 of immune responses as a single therapeutic agent for treatment of immune disorders.
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