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US Patent 11997994 Genetically modified non-human animals with common light chain immunoglobulin locus

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Jiawei Yao0

Huizhen Zhao0

Yabo Zhang0

Yuelei Shen0

Hui Lu0

Yi Yang0

Date of Patent

June 4, 2024

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Patent Application Number

179692540

Date Filed

October 19, 2022

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Patent Citations

US Patent 8791323 Hybrid antibodies comprising human variable regions and mouse constant regions produced in a genetically modified mouse

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US Patent 10194645 Mouse λ light chain locus

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US Patent 10226033 Animal models and therapeutic molecules

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US Patent 10227625 Methods of modifying eukaryotic cells

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US Patent 10251377 Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies

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US Patent 10344299 Compositions and methods for modifying cells

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US Patent 10378037 Methods of making a nucleic acid encoding a human variable region

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US Patent 10378038 Mice that produce hybrid antibodies

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Patent Primary Examiner

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CPC Code

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Patent abstract

This disclosure relates to genetically modified animals and cells with humanized light chain immunoglobulin locus and/or humanized heavy chain immunoglobulin locus. In one aspect, the endogenous light chain immunoglobulin locus comprises a limit number of human IGKV genes and human IGKJ genes.

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