Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
James C. Yang0
Zhiya Yu0
Qiong J. Wang0
Date of Patent
June 4, 2024
0Patent Application Number
169060610
Date Filed
June 19, 2020
0Patent Citations
Patent Primary Examiner
CPC Code
Patent abstract
The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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