US Patent 12011612 Systems and methods for robust radiation treatment planning

The present disclosure is related to systems and methods for generating a radiation treatment plan for a treatment volume of a subject. The method includes retrieving a planning image of the treatment volume. The planning image may include a plurality of first voxels. The method also includes retrieving a treatment image that represents at least part of the treatment volume. The treatment image may include a plurality of second voxels. For at least one of the plurality of second voxels, the method further includes determining at least one reference voxel among the plurality of first voxels in the planning image and determining a dose value corresponding to the at least one second voxel. The method still further includes generating a radiation treatment plan based at least part on the dose value corresponding to the at least one second voxel.