US Patent 12012383 Compositions and methods for inhibiting dihydroorotate dehydrogenase
Patent 12012383 was granted and assigned to Clear Creek Bio, Inc. on June, 2024 by the United States Patent and Trademark Office.
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US Patent 12012383 Compositions and methods for inhibiting dihydroorotate dehydrogenase
Article
Patent abstract
The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
David P. Hesson0
Mo Jia0
Ping Huang0
Vikram S. Kumar0
Xianjun You0
Date of Patent
June 18, 2024
0Patent Application Number
175536370
Date Filed
December 16, 2021
0Patent Citations
0
Patent Primary Examiner
CPC Code
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