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US Patent 12012618 Engineered galactose oxidase variant enzymes

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Deeptak Verma0

Nicholas M. Marshall0

Oscar Alvizo0

Anna Fryszkowska0

Mikayla Jianghongxia Krawczyk0

Margie Tabuga Borra-Garske0

Christopher Michael Micklitsch0

Nandhitha Subramanian0

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Date of Patent

June 18, 2024

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Patent Application Number

179310030

Date Filed

September 9, 2022

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Patent Citations

US Patent 7288375 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

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US Patent 8048674 Methods and compositions for cellular and metabolic engineering

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US Patent 8058001 Oligonucleotide mediated nucleic acid recombination

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US Patent 8076138 Evolution of whole cells and organisms by recursive sequence recombination

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US Patent 8108150 Optimization of crossover points for directed evolution

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US Patent 8170806 Methods of populating data structures for use in evolutionary simulations

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US Patent 8224580 Optimization of crossover points for directed evolution

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US Patent 8377681 Evolution of whole cells and organisms by recursive sequence recombination

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Patent Primary Examiner

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CPC Code

0

Patent abstract

The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

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