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US Patent 12012631 Methods and compositions for isolating asymmetric nucleic acid complexes

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Sassan Sheikholeslami0

Lei Sun0

David Christopher Scherer0

Natasha Popovich0

Date of Patent

June 18, 2024

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Patent Application Number

171504440

Date Filed

January 15, 2021

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Patent Citations

US Patent 8153375 Compositions and methods for nucleic acid sequencing

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US Patent 8241850 Methods and compositions for isolating nucleic acid sequence variants

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US Patent 8658364 Isolation of polymerase-nucleic acid complexes

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US Patent 8715930 Loading molecules onto substrates

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US Patent 8936911 Purified extended polymerase/template complex for sequencing

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US Patent 9416409 Capture primers and capture sequence linked solid supports for molecular diagnostic tests

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US Patent 9267168 Methods and compositions for isolating template nucleic acids

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US Patent 10920268 Methods and compositions for isolating asymmetric nucleic acid complexes

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Patent Primary Examiner

Angela M Bertagna

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CPC Code

0

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Patent abstract

The present disclosure provides improved methods for isolating asymmetrically-primed and/or asymmetrically-tagged nucleic acid complexes that find use in downstream analytical analyses, including sequence analysis. Compositions comprising such complexes and kits and systems for generating such complexes are also provided.

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