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US Patent 12024569 HER2/neu-specific antibodies and methods of using same

Patent 12024569 was granted and assigned to MacroGenics on July, 2024 by the United States Patent and Trademark Office.

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Patent abstract

This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

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