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US Patent 12059408 Treatment of cognitive impairment associated with schizophrenia

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Yihua Zhao0

Sun Young Yum0

Jana Podhorna0

Holger Rosenbrock0

Date of Patent

August 13, 2024

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Patent Application Number

173990940

Date Filed

August 11, 2021

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Patent Citations

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US Patent 8497289 3.1.0 bicyclic GlyT1 inhibitors and methods of making and using same

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US Patent 8816079 Amide derivative and use thereof as medicine

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Patent Primary Examiner

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Patent abstract

The invention relates to the treatment of cognitive impairment associated with schizophrenia (CIAS) with a specific GlyT1 inhibitor ([5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone). A 12-week treatment in a phase 2 study showed improvement in cognitive function as measured by the MATRICS Consensus Cognitive Battery (MCCB) overall composite score.

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