Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael Albert Winters0
Emily Wen0
Jian He0
Jitin Bajaj0
Date of Patent
August 13, 2024
0Patent Application Number
174543360
Date Filed
November 10, 2021
0Patent Citations
Patent Primary Examiner
Patent abstract
The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.
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