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US Patent 12060404 T cell receptors

Patent 12060404 was granted and assigned to Adaptimmune Limited on August, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Adaptimmune Limited

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Current Assignee

Adaptimmune Limited

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Nicholas Tribble0

Eleanor Bagg0

William Lawrance0

Date of Patent

August 13, 2024

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Patent Application Number

175741520

Date Filed

January 12, 2022

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Patent Citations

US Patent 7666604 Modified soluble T cell receptor

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US Patent 7388072 MAGE peptides presented by HLA class II molecules

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US Patent 10117918 Antigen-specific T cell receptors and T cell epitopes

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Patent Primary Examiner

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CPC Code

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Patent abstract

The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.

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